Third Teeth The dated record

Third Teeth · non-commercial · aggregates, does not conduct, research

The third set is the question hiding after the first two.

Humans form deciduous and permanent dentitions. Several programmes now claim they can prompt a third. This publication keeps the dated record of those claims: what was measured rather than asserted, tier by tier, pass by pass.

Read the current pass Programme tracker

Screenprint triptych of three human teeth rendered as negative space against heavy grain, the third tooth cut from the paper's edge
Fig. 01Two dentitions on record. A third, still an open question.
State of the fieldpass 1

Ledger

Latest dated entries

  1. 2009-08-03

    Functional bioengineered tooth replacement in an adult mouse

    bioengineered-tooth-germ T2 · Animal result
  2. 2021-02-12

    Anti-USAG-1 antibody rescues tooth agenesis in mouse models (Science Advances)

    anti-usag-1-trg035 T2 · Animal result
  3. 2024-05-03

    Phase I first-in-human study of TRG-035 announced and registered (Kitano Hospital)

    anti-usag-1-trg035 T3 · Small or narrow human data

Open the full ledger →

Plate I

The biological premise, from rudimentary bud to organized tooth.

Sepia lithograph showing a tooth bud, cap stage, and mature tooth rising through jaw tissue along curved engraved score lines
Plate IA crown alone is not a tooth. Enamel, dentin-pulp, cementum, and ligament must form in time.

Analysis

Latest from the desk

Trial update

What the TRG-035 Phase I record actually establishes

July 28, 2026 · Kitano Hospital (2024), trial announcement; Toregem BioPharma (2026), financing disclosure

The Phase I record shows a single ascending dose tolerated in adults. It says nothing about growing teeth in anyone, and the Phase II population is children with congenital agenesis, not adults.

All analysis →