Independent · non-commercial · evidence on tooth regeneration
Human dentition normally stops after the baby teeth and the permanent teeth. Several research programs claim it does not have to. Third Teeth tracks what those claims are based on: what was actually measured, in which model, and as of what date.
Supersedes the pass of 2026-07-28. Superseded passes are kept, never edited.
Ledger
Plate I
Analysis
In human dental pulp stem cells, an experimental triple antibiotic paste replacing minocycline with nitrofurantoin kept about 75 percent metabolic activity and preserved viability better than Hoshino pastes or calcium hydroxide, an in vitro case for a non-staining REP medicament.
A Jilin University team combines photolithographed cell shapes, a vertex-based simulation, and ex vivo mouse molar germ cultures to show that substrate geometry steers human pulp stem cell polarization and dentin markers through a vinculin-RhoA-YAP axis.
A nine-author perspective maps how blocking USAG-1 might amplify the BMP and Wnt signaling behind cementum, ligament, and bone repair, yet concedes the case is inferential: no one has measured USAG-1 in periodontitis or tested blockade in a periodontal model.