T2
Bioengineered tooth germ (organ germ transplant)
Tsuji lab lineage (Ikeda et al., RIKEN / Tokyo University of Science) · whole-tooth · Animal result
- T1
- T2
- T3
- T4
- T5
Status
Fully functional whole-tooth replacement demonstrated in adult mice (2009). Human cell sourcing and developmental control remain major gaps; no human protocol has been proposed.
What would change this assessment
Independent replication of tooth formation in a large animal by a group with no commercial stake, or a credible human cell-sourcing plan.
Tier history
- 2009-08-03 T2 A transplanted bioengineered tooth germ erupted, occluded, and responded to mechanical and pain stimuli in an adult mouse (Ikeda et al., PNAS).
Sources on file
- Ikeda E, Morita R, Nakao K, et al. (2009). Fully functional bioengineered tooth replacement as an organ replacement therapy. Proceedings of the National Academy of Sciences 106(32):13475-13480. doi:10.1073/pnas.0902944106