T2
Tooth root organoids / whole-tooth reassociation
Academic laboratories (e.g. Syed-Picard lab, University of Pittsburgh) · component · Animal result
- T1
- T2
- T3
- T4
- T5
Status
Root-like organization from human dental stem cells is encouraging. Eruption, crown formation, innervation, and periodontal integration are unresolved.
What would change this assessment
Eruption, crown formation, innervation, and periodontal integration of an organoid-derived construct in an animal jaw.
Tier history
- 2024-05-01 T2 Self-assembled tooth root organoids from postnatal human dental stem cells organize dentin-, pulp-, cementum- and ligament-like tissue; includes in vivo assessment. Eruption, crown, innervation and integration unresolved.
Sources on file
- Calabrese TC, Rothermund K, Gabe CM, et al. (2024). Self-assembly of tooth root organoid from postnatal human dental stem cells. Tissue Engineering Part A 30(9-10):404-414. doi:10.1089/ten.TEA.2023.0219